| PITCHER | TEAM | G | GS | CG | SH | W | L | S | IP | H | R | ER | BB | K | HR | IBB | WP | HB | BK | E | ERA | WPCT |
| HARDEN,Rich | MUN | 24 | 24 | 9 | 4 | 19 | 4 | 0 | 183.0 | 105 | 46 | 38 | 61 | 210 | 13 | 1 | 0 | 3 | 0 | 0 | 1.87 | 0.826 |
| SABATHIA,C.C. | HOU | 35 | 35 | 14 | 3 | 18 | 10 | 0 | 277.7 | 199 | 93 | 80 | 80 | 309 | 16 | 0 | 2 | 1 | 1 | 0 | 2.59 | 0.643 |
| LINCECUM,Tim | HUD | 34 | 33 | 6 | 4 | 19 | 7 | 0 | 244.3 | 196 | 85 | 74 | 81 | 274 | 12 | 2 | 4 | 15 | 1 | 0 | 2.73 | 0.731 |
| JURRJENS,Jair | MLR | 31 | 31 | 4 | 1 | 22 | 7 | 0 | 212.7 | 178 | 76 | 68 | 76 | 158 | 13 | 0 | 1 | 6 | 0 | 0 | 2.88 | 0.759 |
| WEBB,Brandon | MID | 33 | 33 | 8 | 4 | 20 | 9 | 0 | 244.7 | 211 | 88 | 79 | 55 | 171 | 28 | 0 | 0 | 8 | 1 | 0 | 2.91 | 0.690 |
| OLSEN,Scott | RIC | 33 | 33 | 7 | 4 | 15 | 8 | 0 | 226.7 | 191 | 81 | 74 | 54 | 120 | 21 | 0 | 4 | 8 | 0 | 0 | 2.94 | 0.652 |
| DEMPSTER,Ryan | MID | 33 | 33 | 8 | 3 | 19 | 7 | 0 | 235.3 | 186 | 83 | 77 | 72 | 200 | 23 | 0 | 1 | 5 | 0 | 0 | 2.94 | 0.731 |
| SANTANA,Johan | MID | 34 | 34 | 10 | 5 | 20 | 4 | 0 | 254.7 | 204 | 91 | 85 | 72 | 221 | 28 | 1 | 10 | 13 | 0 | 0 | 3.00 | 0.833 |
| LESTER,Jon | MLR | 33 | 33 | 5 | 6 | 20 | 10 | 0 | 239.3 | 168 | 88 | 81 | 88 | 189 | 12 | 0 | 0 | 4 | 0 | 0 | 3.05 | 0.667 |
| HAMELS,Cole | MAR | 33 | 33 | 10 | 4 | 18 | 7 | 0 | 234.3 | 196 | 88 | 81 | 49 | 239 | 33 | 0 | 0 | 8 | 0 | 0 | 3.11 | 0.720 |
| LITSCH,Jesse | RYE | 28 | 28 | 4 | 1 | 13 | 3 | 0 | 197.3 | 194 | 78 | 69 | 49 | 110 | 21 | 0 | 1 | 8 | 0 | 0 | 3.15 | 0.813 |
| PEAVY,Jake | BRO | 26 | 26 | 10 | 0 | 16 | 9 | 0 | 204.3 | 176 | 76 | 72 | 57 | 181 | 24 | 0 | 3 | 6 | 0 | 2 | 3.17 | 0.640 |
| HAREN,Dan | DAL | 33 | 33 | 7 | 2 | 15 | 11 | 0 | 241.0 | 210 | 91 | 86 | 54 | 217 | 25 | 0 | 3 | 7 | 0 | 0 | 3.21 | 0.577 |
| VOLQUEZ,Edinson | MUN | 32 | 32 | 6 | 5 | 17 | 7 | 0 | 226.3 | 169 | 92 | 81 | 102 | 251 | 20 | 2 | 4 | 6 | 0 | 0 | 3.22 | 0.708 |
| SAUNDERS,Joe | MUN | 31 | 31 | 4 | 3 | 18 | 7 | 0 | 204.3 | 185 | 78 | 74 | 60 | 117 | 22 | 2 | 0 | 9 | 0 | 0 | 3.26 | 0.720 |
| LEE,Cliff | GOH | 31 | 31 | 4 | 2 | 15 | 10 | 0 | 228.7 | 198 | 89 | 85 | 49 | 151 | 23 | 0 | 1 | 3 | 0 | 0 | 3.35 | 0.600 |
| BILLINGSLEY,Chad | MLR | 32 | 32 | 5 | 2 | 17 | 8 | 0 | 244.3 | 203 | 99 | 91 | 82 | 196 | 19 | 0 | 2 | 7 | 0 | 0 | 3.35 | 0.680 |
| LOWE,Derek | MUN | 34 | 34 | 4 | 4 | 17 | 6 | 0 | 221.7 | 202 | 89 | 83 | 52 | 149 | 27 | 5 | 2 | 6 | 0 | 0 | 3.37 | 0.739 |
| BURNETT,A.J. | RIC | 34 | 34 | 5 | 3 | 16 | 11 | 0 | 237.7 | 198 | 97 | 90 | 66 | 285 | 24 | 0 | 4 | 8 | 0 | 0 | 3.41 | 0.593 |
| DANKS,John | GOH | 33 | 33 | 3 | 1 | 17 | 7 | 0 | 211.7 | 198 | 97 | 81 | 88 | 149 | 19 | 0 | 4 | 9 | 0 | 2 | 3.44 | 0.708 |
| LOHSE,Kyle | WHT | 33 | 33 | 9 | 7 | 15 | 12 | 0 | 226.3 | 213 | 90 | 89 | 72 | 141 | 24 | 0 | 1 | 5 | 0 | 1 | 3.54 | 0.556 |
| OSWALT,Roy | HUD | 32 | 32 | 3 | 1 | 10 | 11 | 0 | 213.0 | 215 | 95 | 84 | 61 | 170 | 25 | 2 | 2 | 11 | 0 | 0 | 3.55 | 0.476 |
| MOYER,Jamie | GC | 32 | 32 | 5 | 3 | 13 | 8 | 0 | 204.0 | 191 | 92 | 81 | 63 | 136 | 20 | 0 | 0 | 6 | 0 | 0 | 3.57 | 0.619 |
| GARZA,Matt | WHT | 30 | 30 | 2 | 1 | 11 | 9 | 0 | 188.0 | 188 | 93 | 75 | 91 | 134 | 15 | 1 | 3 | 5 | 2 | 2 | 3.59 | 0.550 |
| VERLANDER,Justin | GC | 33 | 33 | 3 | 3 | 11 | 12 | 0 | 212.0 | 209 | 95 | 85 | 78 | 166 | 19 | 0 | 2 | 4 | 1 | 0 | 3.61 | 0.478 |
| WEAVER,Jered | RYE | 30 | 30 | 5 | 3 | 15 | 10 | 0 | 202.0 | 198 | 107 | 81 | 75 | 185 | 22 | 0 | 0 | 3 | 0 | 0 | 3.61 | 0.600 |
| HERNANDEZ,Felix | GC | 31 | 31 | 6 | 0 | 20 | 7 | 0 | 203.7 | 195 | 88 | 83 | 80 | 185 | 17 | 0 | 6 | 8 | 0 | 0 | 3.67 | 0.741 |
| GALARRAGA,Armando | RIC | 28 | 28 | 3 | 2 | 12 | 9 | 0 | 188.0 | 156 | 92 | 81 | 63 | 135 | 28 | 0 | 1 | 8 | 0 | 0 | 3.88 | 0.571 |
| SHIELDS,James | BRO | 33 | 33 | 11 | 3 | 15 | 11 | 0 | 242.0 | 251 | 115 | 105 | 46 | 181 | 26 | 0 | 2 | 9 | 1 | 0 | 3.90 | 0.577 |
| BUSH,David | DAL | 29 | 29 | 5 | 1 | 13 | 11 | 0 | 202.7 | 201 | 98 | 88 | 48 | 134 | 32 | 0 | 0 | 3 | 0 | 0 | 3.91 | 0.542 |
| MARQUIS,Jason | ZIO | 28 | 28 | 3 | 2 | 10 | 12 | 0 | 190.7 | 192 | 89 | 84 | 82 | 113 | 21 | 0 | 3 | 3 | 0 | 0 | 3.97 | 0.455 |
| BLACKBURN,Nick | KNX | 33 | 33 | 3 | 1 | 12 | 14 | 0 | 214.7 | 225 | 109 | 95 | 63 | 126 | 26 | 0 | 1 | 10 | 0 | 0 | 3.98 | 0.462 |
| MADDUX,Greg | ZIO | 33 | 33 | 5 | 1 | 15 | 11 | 0 | 214.0 | 218 | 106 | 95 | 25 | 104 | 31 | 0 | 1 | 3 | 0 | 0 | 4.00 | 0.577 |
| SANTANA,Ervin | MID | 32 | 32 | 6 | 1 | 15 | 14 | 0 | 229.0 | 205 | 107 | 103 | 64 | 256 | 22 | 2 | 2 | 6 | 1 | 0 | 4.05 | 0.517 |
| PARRA,Manny | LV | 29 | 29 | 3 | 2 | 11 | 10 | 0 | 187.7 | 208 | 100 | 85 | 70 | 145 | 20 | 0 | 5 | 6 | 0 | 0 | 4.08 | 0.524 |
| RODRIGUEZ,Wandy | COL | 25 | 25 | 6 | 3 | 12 | 7 | 0 | 169.7 | 165 | 79 | 77 | 40 | 167 | 16 | 0 | 0 | 4 | 0 | 1 | 4.08 | 0.632 |
| SLOWEY,Kevin | COL | 27 | 27 | 5 | 3 | 11 | 13 | 0 | 191.3 | 181 | 93 | 87 | 34 | 166 | 31 | 0 | 0 | 6 | 0 | 0 | 4.09 | 0.458 |
| JIMENEZ,Ubaldo | MLR | 33 | 33 | 2 | 2 | 17 | 8 | 0 | 192.0 | 187 | 98 | 88 | 91 | 149 | 13 | 0 | 7 | 9 | 0 | 0 | 4.13 | 0.680 |
| PELFREY,Mike | ZIO | 32 | 32 | 8 | 1 | 16 | 9 | 0 | 218.0 | 209 | 115 | 100 | 80 | 110 | 15 | 0 | 1 | 4 | 0 | 0 | 4.13 | 0.640 |
| MARCUM,Shaun | LV | 25 | 25 | 5 | 3 | 14 | 8 | 0 | 171.7 | 148 | 88 | 79 | 63 | 131 | 21 | 1 | 1 | 4 | 0 | 0 | 4.14 | 0.636 |
| FLOYD,Gavin | LV | 33 | 33 | 5 | 1 | 12 | 10 | 0 | 228.0 | 198 | 113 | 105 | 81 | 193 | 32 | 2 | 2 | 13 | 0 | 0 | 4.14 | 0.545 |
| GREINKE,Zack | RYE | 32 | 32 | 6 | 1 | 12 | 13 | 0 | 221.0 | 210 | 110 | 102 | 73 | 208 | 25 | 1 | 1 | 11 | 0 | 0 | 4.15 | 0.480 |
| KURODA,Hiroki | LV | 31 | 31 | 1 | 1 | 10 | 11 | 0 | 203.7 | 225 | 103 | 94 | 51 | 127 | 13 | 1 | 2 | 5 | 0 | 0 | 4.15 | 0.476 |
| KAZMIR,Scott | CAY | 27 | 27 | 4 | 2 | 12 | 9 | 0 | 185.3 | 169 | 98 | 88 | 88 | 179 | 26 | 0 | 3 | 7 | 0 | 0 | 4.27 | 0.571 |
| MECHE,Gil | RIC | 34 | 34 | 1 | 1 | 13 | 13 | 0 | 202.0 | 204 | 107 | 96 | 104 | 180 | 24 | 0 | 4 | 1 | 0 | 0 | 4.28 | 0.500 |
| BAKER,Scott | ZIO | 28 | 28 | 2 | 1 | 14 | 12 | 0 | 186.7 | 157 | 96 | 90 | 57 | 184 | 22 | 0 | 4 | 2 | 0 | 0 | 4.34 | 0.538 |
| BECKETT,Josh | WAK | 27 | 27 | 4 | 3 | 9 | 14 | 0 | 188.3 | 194 | 103 | 91 | 58 | 172 | 27 | 0 | 2 | 2 | 0 | 0 | 4.35 | 0.391 |
| GUTHRIE,Jeremy | NW | 30 | 30 | 3 | 1 | 11 | 8 | 0 | 195.7 | 190 | 104 | 95 | 71 | 130 | 24 | 1 | 1 | 15 | 0 | 3 | 4.37 | 0.579 |
| VAZQUEZ,Javier | CAY | 33 | 33 | 5 | 1 | 14 | 11 | 0 | 225.0 | 246 | 130 | 110 | 71 | 213 | 24 | 0 | 1 | 9 | 0 | 0 | 4.40 | 0.560 |
| ZAMBRANO,Carlos | NBO | 30 | 30 | 4 | 2 | 9 | 13 | 0 | 205.0 | 184 | 112 | 101 | 90 | 123 | 28 | 2 | 4 | 6 | 0 | 2 | 4.43 | 0.409 |
| COOK,Aaron | WHT | 32 | 32 | 6 | 3 | 10 | 11 | 0 | 202.7 | 233 | 110 | 100 | 54 | 112 | 16 | 0 | 2 | 8 | 0 | 1 | 4.44 | 0.476 |
| NOLASCO,Ricky | MUN | 32 | 32 | 2 | 1 | 12 | 12 | 0 | 197.7 | 179 | 110 | 98 | 46 | 194 | 40 | 2 | 1 | 6 | 0 | 0 | 4.46 | 0.500 |
| REDDING,Tim | NBO | 33 | 32 | 3 | 1 | 13 | 11 | 0 | 209.0 | 225 | 124 | 104 | 90 | 141 | 20 | 0 | 6 | 11 | 0 | 4 | 4.48 | 0.542 |
| MATSUZAKA,Daisuke | BH | 29 | 29 | 4 | 2 | 10 | 12 | 0 | 200.3 | 162 | 111 | 100 | 110 | 191 | 24 | 0 | 2 | 5 | 0 | 0 | 4.49 | 0.455 |
| MUSSINA,Mike | RIC | 31 | 31 | 1 | 1 | 10 | 9 | 0 | 188.0 | 191 | 97 | 94 | 40 | 151 | 24 | 0 | 1 | 4 | 0 | 0 | 4.50 | 0.526 |
| ZITO,Barry | GOH | 32 | 32 | 2 | 1 | 10 | 13 | 0 | 195.0 | 230 | 104 | 99 | 83 | 120 | 21 | 0 | 3 | 4 | 0 | 1 | 4.57 | 0.435 |
| HALLADAY,Roy | NBO | 33 | 33 | 3 | 0 | 11 | 15 | 0 | 232.7 | 252 | 131 | 120 | 41 | 193 | 26 | 0 | 3 | 4 | 0 | 1 | 4.64 | 0.423 |
| SHEETS,Ben | LV | 31 | 31 | 5 | 1 | 11 | 12 | 0 | 205.0 | 207 | 119 | 106 | 67 | 179 | 20 | 0 | 3 | 10 | 0 | 0 | 4.65 | 0.478 |
| BUEHRLE,Mark | KNX | 34 | 34 | 5 | 2 | 10 | 17 | 0 | 231.3 | 248 | 140 | 120 | 66 | 124 | 31 | 0 | 0 | 11 | 0 | 0 | 4.67 | 0.370 |
| CAIN,Matt | POR | 34 | 34 | 3 | 2 | 9 | 16 | 0 | 230.0 | 230 | 123 | 121 | 102 | 161 | 33 | 0 | 3 | 7 | 1 | 0 | 4.73 | 0.360 |
| WAKEFIELD,Tim | GC | 30 | 30 | 2 | 1 | 11 | 8 | 0 | 185.7 | 182 | 106 | 98 | 67 | 120 | 24 | 0 | 2 | 9 | 0 | 0 | 4.75 | 0.579 |
| BLANTON,Joe | MAR | 32 | 32 | 2 | 1 | 12 | 9 | 0 | 163.0 | 193 | 97 | 89 | 64 | 91 | 10 | 0 | 0 | 4 | 0 | 0 | 4.91 | 0.571 |
| PEREZ,Oliver | HUD | 34 | 34 | 2 | 0 | 10 | 15 | 0 | 224.7 | 211 | 135 | 124 | 110 | 207 | 30 | 4 | 9 | 12 | 1 | 0 | 4.97 | 0.400 |
| PERKINS,Glen | KNX | 26 | 26 | 3 | 3 | 11 | 12 | 0 | 176.7 | 191 | 103 | 98 | 53 | 95 | 35 | 0 | 2 | 9 | 1 | 0 | 4.99 | 0.478 |
| SMITH,Greg | GOH | 32 | 32 | 1 | 1 | 13 | 15 | 0 | 199.0 | 206 | 119 | 111 | 88 | 117 | 24 | 0 | 2 | 7 | 2 | 1 | 5.02 | 0.464 |
| HARANG,Aaron | CAY | 29 | 29 | 4 | 2 | 8 | 12 | 0 | 172.0 | 190 | 103 | 96 | 56 | 127 | 26 | 0 | 1 | 6 | 0 | 0 | 5.02 | 0.400 |
| WELLEMEYER,Todd | MAR | 32 | 32 | 3 | 2 | 14 | 11 | 0 | 176.3 | 177 | 107 | 100 | 68 | 125 | 27 | 0 | 2 | 5 | 0 | 0 | 5.10 | 0.560 |
| PETTITTE,Andy | NBO | 33 | 33 | 3 | 0 | 11 | 12 | 0 | 213.3 | 255 | 138 | 121 | 69 | 180 | 20 | 1 | 3 | 6 | 1 | 5 | 5.10 | 0.478 |
| JOHNSON,Randy | COL | 30 | 30 | 3 | 2 | 9 | 13 | 0 | 184.3 | 200 | 114 | 105 | 58 | 183 | 38 | 0 | 0 | 13 | 0 | 1 | 5.13 | 0.409 |
| LOOPER,Braden | BRO | 33 | 33 | 8 | 4 | 18 | 13 | 0 | 229.7 | 261 | 143 | 131 | 61 | 139 | 32 | 0 | 3 | 9 | 2 | 2 | 5.13 | 0.581 |
| CUETO,Johnny | NW | 31 | 31 | 2 | 1 | 13 | 12 | 0 | 192.7 | 210 | 120 | 110 | 81 | 169 | 24 | 0 | 7 | 10 | 0 | 1 | 5.14 | 0.520 |
| SONNANSTINE,Andrew | COL | 32 | 32 | 5 | 2 | 11 | 17 | 0 | 207.0 | 261 | 127 | 120 | 40 | 125 | 23 | 0 | 3 | 3 | 0 | 0 | 5.22 | 0.393 |
| LILLY,Ted | KAN | 34 | 34 | 3 | 0 | 6 | 22 | 0 | 217.0 | 227 | 130 | 127 | 70 | 210 | 36 | 0 | 2 | 11 | 2 | 0 | 5.27 | 0.214 |
| WOLF,Randy | KAN | 33 | 33 | 1 | 1 | 8 | 17 | 0 | 206.7 | 241 | 137 | 121 | 80 | 148 | 27 | 0 | 2 | 11 | 0 | 7 | 5.27 | 0.320 |
| MAHOLM,Paul | MID | 30 | 30 | 1 | 1 | 11 | 13 | 0 | 178.3 | 192 | 119 | 109 | 71 | 105 | 23 | 0 | 0 | 8 | 1 | 0 | 5.50 | 0.458 |
| BYRD,Paul | BH | 30 | 30 | 0 | 0 | 8 | 16 | 0 | 182.7 | 222 | 119 | 112 | 61 | 133 | 35 | 0 | 0 | 5 | 0 | 3 | 5.52 | 0.333 |
| LANNAN,John | HOU | 32 | 32 | 1 | 0 | 10 | 14 | 0 | 200.7 | 206 | 131 | 125 | 98 | 134 | 26 | 0 | 0 | 0 | 0 | 0 | 5.61 | 0.417 |
| GARLAND,Jon | KAN | 31 | 31 | 2 | 0 | 7 | 14 | 0 | 182.7 | 223 | 120 | 114 | 58 | 100 | 29 | 0 | 1 | 6 | 0 | 0 | 5.62 | 0.333 |
| DUKE,Zach | WAK | 31 | 31 | 4 | 0 | 7 | 19 | 0 | 204.3 | 272 | 151 | 128 | 50 | 125 | 27 | 0 | 1 | 7 | 0 | 0 | 5.64 | 0.269 |
| EVELAND,Dana | COL | 28 | 28 | 2 | 0 | 7 | 16 | 0 | 173.7 | 185 | 125 | 112 | 95 | 142 | 22 | 0 | 3 | 5 | 0 | 2 | 5.80 | 0.304 |
| PADILLA,Vicente | WAK | 29 | 29 | 2 | 1 | 6 | 18 | 0 | 187.0 | 219 | 129 | 121 | 72 | 133 | 26 | 0 | 7 | 3 | 0 | 0 | 5.82 | 0.250 |
| SANCHEZ,Jonathan | CAY | 29 | 29 | 1 | 0 | 9 | 13 | 0 | 171.7 | 208 | 142 | 113 | 99 | 176 | 19 | 0 | 3 | 6 | 0 | 0 | 5.92 | 0.409 |
| KENDRICK,Kyle | WAK | 30 | 30 | 3 | 1 | 3 | 15 | 0 | 171.3 | 243 | 126 | 119 | 60 | 112 | 27 | 0 | 2 | 4 | 0 | 0 | 6.25 | 0.167 |
| SNELL,Ian | KNX | 31 | 31 | 1 | 1 | 6 | 17 | 0 | 171.0 | 233 | 151 | 133 | 93 | 148 | 26 | 0 | 5 | 9 | 0 | 0 | 7.00 | 0.261 |
| PENNY,Brad | BRO | 26 | 26 | 7 | 1 | 4 | 19 | 0 | 169.0 | 249 | 158 | 132 | 64 | 102 | 30 | 0 | 2 | 6 | 0 | 1 | 7.03 | 0.174 |
| BANNISTER,Brian | BH | 32 | 32 | 2 | 0 | 6 | 22 | 0 | 188.7 | 271 | 168 | 151 | 88 | 120 | 32 | 0 | 2 | 7 | 0 | 3 | 7.20 | 0.214 |
| SILVA,Carlos | KNX | 28 | 28 | 3 | 0 | 6 | 17 | 0 | 162.0 | 267 | 139 | 135 | 47 | 107 | 28 | 0 | 1 | 8 | 0 | 0 | 7.50 | 0.261 |
| OLSON,Garrett | POR | 32 | 31 | 0 | 0 | 1 | 22 | 0 | 178.0 | 283 | 167 | 157 | 69 | 118 | 30 | 0 | 9 | 5 | 0 | 0 | 7.94 | 0.043 |
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